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MBI Boot Camp: How to Simulate and Analyze Your Cancer Models with COPASI

Month: September 2014

Date: September 29--October 1

Name: MBI Boot Camp: How to Simulate and Analyze Your Cancer Models with COPASI

Location: Mathematical Biosciences Institute, The Ohio State University, Jennings Hall 3rd Floor, 1735 Neil Ave., Columbus, Ohio.


Mathematical models typically start out in simple form. One writes down a few differential equations, estimates the parameters, explores the output, and checks to see if it can predict behavior reasonably well. After that, the process begins to take on a life of its own. Since the model is greatly abstracted and simplified, it captures some aspects of the system, but fails in others, so new variables and more inputs are added. Alternative mechanisms are investigated. At some point, the question arises: How can one tell if this is a good model?


The aim of this bootcamp is to provide tools that provide good cancer models. We will frame the question in a way that respects both the biology and the underlying mathematics. Two organizers of the bootcamp, Pedro Mendes and Stefan Hoops, have spent the last twenty years creating a bridge between these paradigms, in the form of a software package called COPASI (COmplex PAthway SImulator). COPASI is a simulation software that allows one to translate the biochemical interactions between species into dynamical systems represented by the sets of either stochastic or deterministic equations. COPASI developers have created a user-friendly graphical interface, which can help researchers to apply sophisticated analytical tools to their models. This workshop provides an introduction to the ease and power of the software.

Information; phone: 614-292-3648.