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MBI Workshop on Tumor Heterogeneity and the Microenvironment

Month: February 2015

Date: February 2--6

Name: MBI Workshop on Tumor Heterogeneity and the Microenvironment

Location: Mathematical Biosciences Institute, The Ohio State University, Jennings Hall 3rd Floor, 1735 Neil Ave., Columbus, Ohio.


Most solid tumors present as dense fibrotic masses, which suggests that fibroblasts contribute to tumor growth by infiltrating and depositing extracellular matrix proteins. Fibroblasts act in wound healing, angiogenesis and tissue remodeling by releasing growth factors and proteases such as matrix metalloproteinases. Therefore, if the growing tumor can co-opt such fibroblasts it has an unlimited source of many of the fundamental elements required for growth and invasion. The two central themes of this workshop are: - Heterogeneity (be it phenotypic, signaling or genotypic), and - Microenvironment (ECM, nutrients, fibroblasts and immune cells). Since a highly heterogeneous tumor has the potential to adapt to any microenvironment, understanding how interactions between the growing tumor and its microenvironment modulate tumor heterogeneity is critical to unraveling the mechanisms of cancer initiation.

Information; phone: 614-292-3648.