Mathematics of Sequence Evolution: Biological Models and Applications
Month: September 2013
Date: September 23--27
Name: Mathematics of Sequence Evolution: Biological Models and Applications
Location: Centre de Recherches Mathématiques, Montréal, Canada.
Models of evolution of biological sequences have gone a long way since Jukes and Cantor. First, it is no longer acceptable to consider that mutations of a given type occur independently and uniformIy across time and space. A large number of factors affect the rate at which mutations occur. Second, selective pressure makes that the probability of fixation of a mutation depends on the fitness of the mutated individual, which sometimes places unexpected constraints on the mutational process and induces strong dependencies between positions along the sequences.
Financial support is available.